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156 M1 macrophages are characterized by enhanced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), production of reactive oxygen species (ROS) through NADPH oxidase, and robust secretion of pro-inflammatory cytokines including TNF- α , IL-1β, IL-6, IL-12, and IL-23
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This may reflect specific Se-dependent cellular functions, or differences in the levels of factors that activate GPX4
it could be used for the suggested purposes.
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