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Thus, there were increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy in glaucomatous rats [11]
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Despite these encouraging results, opicinumab failed to reach its primary end points in both the SYNERGY and AFFINITY phase II trials in PwMS 202
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