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IGF-1 DES can cause insulin-like glucose lowering, but its rapid clearance limits the duration of hypoglycemic risk compared to longer-acting variants Local tissue effects : Site-specific administration may cause localized tissue growth or hypertrophy at the injection site, which can be asymmetric if injection sites are not rotated Injection site reactions : Pain, redness, and swelling at the injection site are commonly reported Headache and dizziness : Transient effects possibly related to glucose fluctuations Joint pain : Less common than with sustained IGF-1 signaling due to shorter exposure duration Theoretical cancer risk : As with all IGF-1 analogs, enhanced mitogenic signaling raises theoretical concerns about promoting growth of pre-existing neoplasms The short half-life of IGF-1 DES is arguably a safety advantage, as any adverse effects resolve rapidly with discontinuation

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Along with the conventional oxidative stress markers, this review also discusses the role of novel markers, focusing on their biological samples and detection techniques