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141,142 Secondly, Akkermansia muciniphila can regulate the hepatic immune microenvironment through the TLR2-γδT17 cell axis by secreting cytokines such as IL-17A and IL-22 as well as regulating the conversion of macrophages into anti-inflammatory macrophages, which in turn reduces hepatic inflammation

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Fast-twitch fibers undergo a more pronounced decline in mitochondrial volume, cristae integrity, and oxidative enzyme activity, rendering them particularly vulnerable to age-related atrophy, whereas slow-twitch fibers retain greater mitochondrial functionality and structural connectivity, partially preserving their endurance capacity despite senescent stressors (Marzetti et al., 2024)