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FIP200 is thought to initially localize to phosphatidylinositol synthase (PIS)-enriched ER subdomains prior to PI(3)P generation by the autophagic PI 3-kinase complex I (Nishimura et al., 2017)
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These toxic metals can also disrupt redox signaling, enhance calcium influx, and activate downstream pathways like NF-κB, further amplifying cytokine production and inflammation (Chen & Shi, 2002
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