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Here, CPT can activate NADPH oxidase, increasing the H 2 O 2 level within the tumor, thereby “fueling” the supply of Pd nanozymes with POD activity, enabling them to efficiently produce ·OH, amplifying oxidative stress, and synergistically inducing tumor cell apoptosis
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Similarly, increased plasma serotonin levels may explain the mechanism associated with diarrhea in LC patients as reported in acute COVID-19 (71)
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