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Most recently, investigations have shifted towards specific NLRP3 inhibitors (Figure 2)
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MMPs 1 and 13 predominate in RA due to their capacity to restrict the collagen degradation rate, while MMP13 is considered to have a dual role in RA because of its capability to degrade aggrecan and proteoglycan, suggesting that it has a dual role in ECM destruction in RA [219,220]
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