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6 1996 Strategy for the Design of Non-Peptidic Inhibitors¶ Successful Design of a Non-Peptidic Inhibitor¶ articles Structure Based Drug Design: the Discovery of Novel Non-Peptide Orally Active Inhibitors of Human Renin Rahuel J, Rasetti V, Maibaum J, Rueger H, Goeschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM and Gruetter M Chemistry & Biology 7 2000 Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R and D pipeline challenge Nissim Claude Cohen Chem Biol Drug Des 70(6) 2007 10.1111/j.1747-0285.2007.00599.x Optimization of the Tetrahydroquinoline Inhibitor¶ articles Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R and D pipeline challenge Nissim Claude Cohen Chem Biol Drug Des 70(6) 2007 10.1111/j.1747-0285.2007.00599.x A Third Generation of Renin Inhibitors¶ Alignment of the Non-Peptide Inhibitors in 3D¶ Case Study-5 : Inhibitors of HLE¶ Inhibition of Human Leukocyte Elastase¶ Problem of Peptide-Based ICI-200,880¶ articles Biologic Characterization of ICI 200,880 and ICI 200,355, Novel Inhibitors of Human Neutrophil Elastase Williams JC, Falcone RC, Knee C, Stein RL, Strimpler AM, Reaves B, Giles RE and Krell RD Am

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List of Abbreviation ΔΨm Mitochondrial membrane potential 6-OHDA 6-hydroxydopamine BBB Blood-brain barrier CAT Catalse CGNs Cerebellar granular neurons CREB cAMP responsive element-binding protein (CREB) IPQ Imidazole pyrroloquinoline LDH Lactate dehydrogenase MMP Matrix metalloproteinase MTFA Mitochondrial transcription factor A NGF Nerve growth factor NMDA N-methyl-D-aspartate NO Nitric oxide NRF-1 Nuclear respiratory factor 1 NRF-2 Nuclear respiratory factor 2 PASMCs Pulmonary artery smooth muscle cells PGC-1α Peroxisome proliferator-activated receptor-γ coactivator-1α PH Pulmonary hypertension Pyrroloquinoline Quinone PQQC Pyrroloquinoline quinone synthase C ROS Reactive oxygen species SOD Superoxide dismutase TBARS Thiobarbituric acid reacting substances TBI Traumatic brain injury Data availability No data was used for the research described in the article