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First, with other drugs the precise chemical mechanism whereby they cause oxidative damage is not fully understood: for rasburicase – a genetically engineered form of the enzyme urate oxidase – we know instead that, like all other oxidases, one of the products of the enzyme reaction is hydrogen peroxide, of which one molecule is produced stoichiometrically for every molecule of uric acid that is catabolized

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These are recognized effects of elevated growth hormone activity and can manifest as mild edema or carpal-tunnel-like symptoms

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