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Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signaling
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Not only do we see activation of microglia in the region of insult but also migration of activated microglia to other sites occurs as the process spreads.[162,246] It is known that microglia are heterogeneously distributed in the nervous system, making some areas of the brain and spinal cord more vulnerable than others.[57,134] For example, the substantia nigra is known to have one of the highest concentrations of microglia in the brain.[124] Before discussing the immunoexcitotoxic process, I will discuss the evidence for a role of inflammation in Parkinson's disease
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