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However, the lack of comprehensive studies exploring the precise mechanisms underlying this modulation leaves significant gaps in our understanding and warrants further investigation

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a high-cardiovascular-risk kidney cohort showed a slower decline in kidney function and about a third less protein leak, which travels to a similar-risk body, not a healthy one.⁶ ¹⁴ Lean and metabolically healthy: a safety read, not an efficacy target No long trial has tested tirzepatide in lean, metabolically healthy people