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This Gi–Gβγ–MAPK coupling has been directly demonstrated for Gi-coupled receptors such as the melatonin MT 1 R and MT 2 R, where ERK and c-Jun N-terminal kinase (JNK) activation proceeds via a PTx–sensitive, Gβγ-, Ras/Rac-, and Src-dependent mechanism [132]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Taha A.Y
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