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The first is the oxidative stress-mitochondrial damage type, which may be characterized by elevated cf-mtDNA, 8-OHdG, and MDA, along with abnormal mitokines such as GDF15 and FGF21, indicating high mitochondrial stress and systemic metabolic burden (258)

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Insulin signaling pathway components, mammalian uncoordinated-18c (Munc18-c), and forkhead box O1 (FOXO1) are modified with O-GlcNAc

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