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Neuroinflammatory mediators and neurotrophic factors such as NGF further amplify nociceptor excitability [89]
سيروم نياسيناميد وجلوتاثيون
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251 , 266 Meanwhile, the immune dysregulation caused by microbiota disorder (such as the increase of TNF-α) further aggravates the inhibition of tight junction protein expression, 265 , 404 suggesting a vicious cycle of “microbiota imbalance-barrier damage-LPS translocation-inflammatory amplification,” providing new ideas for the mechanism research of NDs
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