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Moreover, intracellular staining for IL-5 and IL-13 ( Supplementary Figures 4H–I ), corroborated with our previous findings that melatonin ILC2s produced less cytokine than vehicle treated controls ( Supplementary Figures 4B–F, H, I )

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Curcumin exerts its antioxidant function directly on the NF-κB pathway by inhibiting the degradation of IκBα in the cytoplasm and reducing the phosphorylation level of p65 in the nucleus (Chen et al., 2019), thereby reducing the oxidative stress driven by inflammatory cytokines