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Particularly insightful mechanistic evidence comes from a medaka fish NAFLD model, where metabolomic analysis revealed that L-carnitine not only reduced hepatic lipid deposition but also significantly elevated hepatic β-oxidation end products (acetyl-CoA and ATP) while upregulating antioxidant enzyme superoxide dismutase 2 (SOD2) (35)
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B12 supplements are appropriate when there is a confirmed or suspected deficiency of this specific vitamin, or when an individual belongs to a high-risk group (such as vegans, older adults, or those with malabsorption conditions)
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