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5 : 655–665 Jacquier-Sarlin MR and Polla B (1996) Dual regulation of heat shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin
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In the ER/secretory pathway, Prx4 and GPx7/8 work alongside protein-disulfide isomerase (PDI) cycles to manage the purposeful H 2 O 2 generated during oxidative folding, with only limited catalase present, so peroxidase-based redox relays carry much of the detox and signaling burden (Gansemer and Rutkowski 2022)
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