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home > melanotan 2 org II Spray (10mg Per Bottle) medical #knowledge #๐Ÿง‘โ€โš•๏ธ๐Ÿฉบโš•๏ธ๐Ÿ’‰๐Ÿ’Š๐Ÿ˜”๐Ÿฅบ > melanotan 2 org II Spray (10mg Per Bottle) medical #knowledge #๐Ÿง‘โ€โš•๏ธ๐Ÿฉบโš•๏ธ๐Ÿ’‰๐Ÿ’Š๐Ÿ˜”๐Ÿฅบ
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melanotan 2 org II Spray (10mg Per Bottle) medical #knowledge #๐Ÿง‘โ€โš•๏ธ๐Ÿฉบโš•๏ธ๐Ÿ’‰๐Ÿ’Š๐Ÿ˜”๐Ÿฅบ
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melanotan 2 org II Spray (10mg Per Bottle) medical #knowledge #๐Ÿง‘โ€โš•๏ธ๐Ÿฉบโš•๏ธ๐Ÿ’‰๐Ÿ’Š๐Ÿ˜”๐Ÿฅบ

medical #knowledge #๐Ÿง‘โ€โš•๏ธ๐Ÿฉบโš•๏ธ๐Ÿ’‰๐Ÿ’Š๐Ÿ˜”๐Ÿฅบ

(6)ๅˆถๅค‡Fmoc-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin (6) Preparation of Fmoc-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin ๅœจๆญฅ้ชค(5)็š„Fmoc-Asp(otBu)-Ala-Gly-Leu-Val-WangResinไธญ๏ผŒๅŠ ๅ…ฅ่„ฑๅธฝ่ฏ•ๅ‰‚(20๏ผ…ๅ“Œๅ•ถ็š„DMFๆบถๆถฒ)๏ผŒๅธธๆธฉๅๅบ”5ๅˆ†้’Ÿ๏ผŒๆŠฝๅนฒ๏ผŒ้‡ๆ–ฐๅŠ ๅ…ฅ่„ฑๅธฝๅ‰‚ๅธธๆธฉๅๅบ”20ๅˆ†้’Ÿ๏ผŒ็”จๅผ‚ไธ™้†‡ๆด—ๆถค3ๆฌก๏ผŒDMFๆด—ๆถค3ๆฌก๏ผŒ้‡่’ธ่ฟ‡็š„DMFๆด—ๆถค2ๆฌก๏ผŒๆŠฝๅนฒ๏ผŒๅŠ ๅ…ฅFmoc-Asp(otBu)-OH1.1g๏ผŒDIEA0.4ml๏ผŒTBTU0.56g๏ผŒHOBT0.2g๏ผŒDMF10mlๅธธๆธฉๅๅบ”1.5ๅฐๆ—ถ๏ผŒ็”จ็œŸ็ฉบๆณตๆŠฝๅนฒ๏ผŒ็”จๅผ‚ไธ™้†‡ๆด—ๆถค3ๆฌก๏ผŒDMFๆด—ๆถค3ๆฌก๏ผŒ้‡่’ธ่ฟ‡็š„DMFๆด—ๆถค2ๆฌก๏ผŒๆŠฝๅนฒ๏ผŒ่Žทๅพ—Fmoc-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-WangResin๏ผ› In the Fmoc-Asp(otBu)-Ala-Gly-Leu-Val-WangResin in step (5), add decapping reagent (20% piperidine in DMF solution), react at room temperature for 5 minutes, drain, and add decapping reagent at normal temperature React for 20 minutes, wash with isopropanol for 3 times, DMF for 3 times, DMF for redistilled for 2 times, drain, add Fmoc-Asp(otBu)-OH1.1g, DIEA0.4ml, TBTU0.56g, HOBT0 .2g, DMF10ml normal temperature reaction for 1.5 hours, drained with a vacuum pump, washed 3 times with isopropanol, washed 3 times with DMF, washed 2 times with DMF evaporated, and dried to obtain Fmoc-Asp(otBu)-Asp(otBu )-Ala-Gly-Leu-Val-WangResin

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melanotan 2 org II Spray (10mg Per Bottle) medical #knowledge #๐Ÿง‘โ€โš•๏ธ๐Ÿฉบโš•๏ธ๐Ÿ’‰๐Ÿ’Š๐Ÿ˜”๐Ÿฅบ

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