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This method enables assessment of NP-induced protein expression changes, such as altered KIF11 and MYC levels following siRNA-loaded NP treatment [409], detection of apoptotic proteins after NP-mediated drug delivery [413] and confirmation of SPAK knockdown by siRNA NP [414], RVG-targeted nanoparticle-mediated knockdown of caspase 3 [404]
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Initially identified due to its involvement in the toxicity of dioxins such as TCDD, AhR predominantly resides in the cytoplasm in an inactive state, complexed with chaperone proteins, including HSP90, AIP and p23
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