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A 2021 review and meta-analysis on the effects of betaine on cardiovascular markers describes a “lower dose” as under 4g per day, and the examined trials used daily doses ranging from 1.5g all the way up to 20g.40 Coenzyme Q10 (60mg) Though most studies use higher doses of CoQ10 (100-200mg), a dose of 60mg has shown some success in research.42 An older 2006 study, for example, found that 60mg led to a “significant improvement” in functional status, symptoms, and quality of life in heart transplant candidates.43 And a more recent 2024 trial found that 300mg CoQ10 phytosome — equivalent to 60mg CoQ10 — “significantly” enhanced the physical performance of older adults with statin-associated asthenia (generalized weakness).44 Codeage isn’t using that phytosome technology, but it’s worth noting the dosing similarity nonetheless