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CD38 is one of the main NAD degrading enzymes in mammalian tissues, and plays a key role in age-related NAD decline

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l INDICATIONS AND DOSE BUDENOFALK ® CAPSULES Mild to moderate Crohn’s disease affecting the ileum and/or ascending colon ▶ BY MOUTH Adult: 9 mg once daily for up to 8 weeks, to be taken in the morning, alternatively 3 mg 3 times a day for up to 8 weeks, reduce dose gradually over 2 weeks following treatment course before stopping Microscopic colitis, induction of remission ▶ Adult: 9 mg once daily for up to 8 weeks, to be taken in the morning, reduce dose gradually over 2 weeks following treatment course before stopping Microscopic colitis, maintenance ▶ BY MOUTH Adult: 6 mg once daily, to be taken in the morning, alternatively 6 mg once daily and 3 mg once daily, to be taken on alternate mornings, review treatment regularly and no later than 12 months after initiation of maintenance treatment, treatment may be extended to beyond 12 months if required, when stopping treatment, reduce dose gradually over 2 weeks Autoimmune hepatitis, induction of remission ▶ ▶ BY MOUTH Adult: 3 mg 3 times a day until remission is achieved, reduce dose gradually over 2 weeks following treatment course before stopping Autoimmune hepatitis, maintenance ▶ Adult: 3 mg twice daily for at least 24 months, when stopping treatment, reduce dose gradually over 2 weeks BUDENOFALK ® GRANULES Mild to moderate Crohn’s disease affecting the ileum and/or ascending colon | Microscopic colitis, induction of remission ▶ BY MOUTH ▶ ▶ BY MOUTH l 10-Nov-2022 DRUG ACTION Budesonide is a glucocorticoid, which exerts significant local anti-inflammatory effects