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Although this approach can be effective, it has largely been supplanted by immobilized metal or metal oxide affinity chromatography (iMAC or MOAC) (400, 401) (FIGURE 8)

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143 The fluorescence, photoacoustic, and PET imaging of the CD44 overexpressing tumors have been imaged using quantum dots, gold nanoparticles, and upconversion nanoparticle functionalized with HA