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6.3.3 Dual GPX4/FSP1 combination therapies Because FSP1 and GPX4 operate as parallel, mutually compensatory cellular safeguards against lipid peroxidation, targeting a single pathway often triggers compensatory upregulation of the other, limiting monotherapy efficacy (41)
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[DOI] [PubMed] [Google Scholar] 280.Perlman S, Jacobsen G, Afifi A
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