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SCFAs produced by microbiota affect mitochondrial function, for example, the lack of butyrate led to a significant reduction in nicotinamide adenine dinucleotide (NAD), resulting in autophagy in germ-free mouse colon cells [30]
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PCE (84 mg/kg) regulates the interferon regulatory factor 5 (IRF5)-IRF4 axis, inhibiting M1 microglial polarization and promoting M2 polarization, reducing pro-inflammatory cytokine secretion and increasing anti-inflammatory cytokine release
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