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These effects have been recently associated with several molecular pathways [10,11,20,58,59,60,61,62,63,64,65,66], in particular with the increased expression and internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway [60,61], interacting particularly with the NO [49] and prostaglandins systems [50]
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For a researcher who wants to explore this combination in vitro or preclinically, it is precisely a good topic for original research, not an established fact
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