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The mechanism works at the cellular level through several pathways simultaneously: PDGF (Platelet-Derived Growth Factor): Stimulates cell replication and promotes hair follicle growth by activating stem cells in the hair bulge region VEGF (Vascular Endothelial Growth Factor): Promotes formation of new blood vessels (angiogenesis) around hair follicles, improving nutrient and oxygen delivery to the follicle EGF (Epidermal Growth Factor): Supports cell growth, differentiation, and proliferation — helps transition follicles from the resting phase (telogen) back to the growth phase (anagen) TGF-beta (Transforming Growth Factor): Regulates hair follicle cycling and stimulates the dermal papilla cells that control hair growth FGF (Fibroblast Growth Factor): Promotes wound healing and supports the structural integrity of the hair follicle IGF-1 (Insulin-like Growth Factor): Promotes cell growth and protects cells from programmed cell death (apoptosis) The net effect of these growth factors is threefold: they prolong the anagen (growth) phase of the hair cycle so each hair grows for longer before shedding, they increase the diameter of individual hair shafts making existing hair appear thicker, and they can reactivate dormant follicles that have entered an extended resting phase