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Additionally, BPC 157 treatment of esophagogastric anastomosis along with a NO-synthase (NOS) blocker, L-NAME, and/or NOS substrate L-arginine would evidence an innate NO-system disability, and investigate the effect on the corresponding worsening (obtained with L-NAME administration) or amelioration (due to L-arginine)

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In 1875, American physician and educator William Pepper Jr