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To graphically visualize dose-response associations and assess log-linearity, we fitted Cox models with restricted cubic splines (3 knots)
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MAM activates and binds to quinone oxidoreductase 1 (NQO1) which triggers ROS generation, unstable iron pool (LIP) expansion, and lipid peroxidation, activating NQO1-mediated ferroptosis to combat drug resistance
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