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Accordingly, systematic structure–activity relationship (SAR) studies are essential for elucidating the activation thermodynamics and selectivity constraints of 1,2-dithiolane systems bearing distinct cargoes, which support that the recognition site 1,2-dithiolane, the linker unit, and the leaving group in a cargo coordinate to determine the selectivity triggered by TrxR (Fig

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With BPC 157 therapy, given as local bath at the swollen brain, but also intraperitoneal and intragastric application, µg- and ng-regimens, at 1 min, 15 min, 24 h or 48 h ligation-time, the increased (positive) pressure in the superior sagittal sinus is immediately reversed to the normal (negative) pressure