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Key Findings Combination of cagrilintide 2.4 mg plus semaglutide 2.4 mg produced approximately 15.7% weight loss at 20 weeks Combination was well tolerated with acceptable safety profile Most adverse events were mild to moderate gastrointestinal effects Supported advancement of CagriSema combination to phase 2 and 3 development Limitations: Phase 1b study with primary PK/PD endpointsRelatively short treatment duration (20 weeks)Small sample size per cohort Efficacy and safety of cagrilintide plus semaglutide in type 2 diabetes: a multicentre, randomised, double-blind, phase 2 trial Frias JP, Deenadayalan S, Erichsen L, Knop FK, Lingvay I, Machineni S, Mathieu C, Philis-Tsimikas A, Rosenstock J (2023) • The Lancet Phase 2 randomized, double-blind trial evaluating CagriSema (cagrilintide plus semaglutide) in patients with type 2 diabetes, assessing glycaemic control and body weight outcomes

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61 , e202204788 (2022)