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The clinical significance of mast cell-derived histamine in CVD is evident from the finding that coronary arteries of patients with ischemic heart disease contain more mast cells and histamine than normal vessels (103), and patients with variant angina have elevated levels of histamine in their coronary circulation (127)

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The fundamental difference Steroids: Exogenous hormones that replace/supplement your natural production Peptides: Signaling molecules that enhance your natural hormone production and cellular processes This distinction matters enormously for side effects, safety, and long-term health implications

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