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Reduced GSH produced in human adults from oxidized GSSG primarily by the liver, and to a smaller extent, by the skeletal muscle, red blood cells, and white cells
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This review examines the molecular mechanisms through which red blood cells adapt to hypoxic conditions, including nitric oxide (NO)-driven changes in membrane properties, βCys93-dependent S-nitrosylation, adenosine-induced activation of glycolysis, and the development of hypoxic memory via eENT1 degradation
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