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The Q126X mutation in ABCG2 (encoded by SNP rs72552713 ) encodes an entirely nonfunctional ABCG2, and carriage of this allele is a major factor in intestinal (extra-renal) underexcretion of urate with renal uric acid overload (without uric acid overproduction) ( Figure 1 - 5 )
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Liver X receptor α mediates hepatic triglyceride accumulation through upregulation of G0/G1 switch gene 2 expression
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