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Although the age-adjusted mortality rate for cardiovascular disease has diminished in industrialized countries owing to life-style changes, smoking cessation, advances in biomedical research, and improvements in medical care and technologies, the aging population and burgeoning epidemic of cardiometabolic disease characterized by obesity, insulin resistance, dyslipidemia, impaired glucose tolerance, and hypertension, threatens to reverse this progress, underscoring the requirement for additional therapeutic options that target this deadly disease

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The following FDA-approved drugs have been tested in FXS preclinical and clinical studied: acamprosate (for maintenance of alcohol abstinence), lovastatin (for hypercholesterolemia), minocycline (for acne) and metformin (for non-insulin diabetes mellitus)