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Using several such ensembles, AR6 WGI Box 4.1 assessed that the 5–95% ensemble range of annual mean global surface air temperature is approximately ±0.25 °C (MIROC6, IPSL-CM6A), spanning from about ±0.2 °C (CanESM5) to ±0.3 °C (EC-Earth3)

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Thus, the effect of DSIP on coping with acute and long-term stress largely depends on the changes in the levels of other oligopeptides and hormones that DSIP induces