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Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson’s disease
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However, chronic ethanol exposure disrupts autophagic flux, for example, by impairing autophagosome–lysosome fusion or by dysregulating key regulators such as mTOR, Beclin-1 and LC3, which leads to the accumulation of dysfunctional mitochondria and toxic protein aggregates [7,35]
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