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In canonical Wnt/β-catenin signaling, the secreted Wnt proteins bind with the Frizzled receptor and a co-receptor of the low-density lipoprotein-related protein (LRP), thereby inactivating glycogen synthase kinase-3β (GSK-3β), which is an enzyme responsible for phosphorylation and ubiquitination-mediated degradation of β-catenin
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