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For statistical analysis, the amount of hippocampus-dependent compared to hippocampus-independent strategies at each day can be compared to non-transgenic (ntg) littermates (Figure 2A)

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H 2 O 2 can react with ferrous ions in a reaction known as the Fenton reaction to generate the short-lived hydroxyl radicals, which are highly toxic and can cause irreversible damage to essentially all types of cellular macromolecules, including nucleic acids (e.g., mutations), lipids (e.g., oxidized lipids such as 4-HNE), and proteins (e.g., protein carbonylation) [3,4,5]