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Affinity Chromatography | Principles
Induction of HO-1 results in the release of CO, which regulates the activity of transcription factors such as NRF-1 and PGC-1α through the Akt, AMPK, MAPK, and Sirt1 pathways, thereby promoting the expression of these transcription factors and the generation of antioxidant enzymes involved in mitochondrial biosynthesis
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