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Mycobacterium smegmatis expands across surfaces using hydraulic sliding | bioRxiv

Renal tubules treated ex vivo with erastin exhibited synchronized death responses that could spread between cells and were inhibited by treatment with the lipophilic antioxidant and ferroptosis inhibitor ferrostatin-1, leading the authors to posit that the observations “suggest a direct cell-to-cell communication to deliver the deadly signal” [24]

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However, a disturbance in the balance between ROS production and cellular antioxidant defenses can lead to an excessive ROS buildup, causing oxidative stress