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Dihexa Side Effects: The No-Human-Data Reality (2026)
Formation of hexa- and decadepsipeptides via NRPS misoperation is key to form the isocereulides E, F and G, whereas peptide assembly in the biosynthesis of isocereulides A-D corresponds well to that of cereulide differing that L- O -Val is substituted by L- O -Leu (isocereulide A), L-Val by L-Ala (isocereulide D), D-Ala by D-Ser (isocereulide C) and D-O-Leu by D-O-Val (isocereulide B) due to a relaxed substrate specificity of the A domains and/or an inefficient proof reading by CesT
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