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ROS can activate early growth response gene 1 (Egr-1), which further activates RIPK1 and RIPK3, and initiating the necroptotic pathway
Centella
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Ultimately, the gut microbiota can now be regarded as a crucial “distal regulator” of OA pathogenesis in many ways including regulation of the intestinal barrier function, effect on immune-inflammatory mechanisms and regulation of host metabolic disorders
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