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Available online at: Summary Keywords HSCT, PBPK modeling, DDIs, pharmacokinetics, personalized dosing Citation Wang P, Lu J and Yang J (2025) Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages

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4.1The GH / IGF-1 Axis and Secretagogue Classes Hypothalamic–pituitary–somatotroph physiology and pulsatile GH release GHRH receptor versus ghrelin receptor (GHS-R1a) signaling and why the two classes are combined IGF-1, IGFBP-3 and the acid-labile subunit: what each lab value represents Somatostatin tone, sleep-stage timing and the rationale for pre-sleep dosing Adult GH deficiency: diagnostic criteria, stimulation testing and the diagnostic role of macimorelin Secretagogue stimulation versus exogenous recombinant GH — clinical, legal and ethical distinction Per-agent regulatory divergence within the class: why GHRP-2/GHRP-6, ipamorelin and tesamorelin are not interchangeable 4.2GHRH Analogs and Ghrelin-Receptor Agents in Practice Sermorelin and the GRF(1-29) sequence