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Finasteride, a 5-alpha reductase inhibitor that reduces DHT production, addresses the hormonal component of androgenetic alopecia but carries a well-documented profile of systemic side effects including sexual dysfunction, mood disturbance, and — in a subset of patients — persistent post-treatment syndrome

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In addition to inhibiting NF-kB signaling, riboflavin can also inhibit critical components of the non-canonical inflammasomes, such as caspase-1 activity 47 , either via the AIM2 cytosolic innate immune receptor, which recognizes double-stranded DNA (dsDNA) released during cellular perturbation, or via the Nod-like receptor NLRC4, which recognizes bacterial ligands such as flagellin and the type three secretion system (T3SS) 47