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This figure depicts the dysregulation of the HPA axis in PTSD, highlighting the altered cortisol secretion patterns due to impaired negative feedback

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However, the underivatized native GLP-1 (7–36 amide or 7–37 acid, Figure 1) has a short half-life in vivo (1.5–5 min), primarily caused by the high renal clearance and proteolysis, generating the main metabolite GLP-1 (9–36 amide) with several orders of magnitude lower potency toward GLP-1R