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Of note, the vast majority of residual HIV replication and HIV reservoirs (including macrophages) reside in sanctuary sites such as the gut, adipose tissue and brain
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Moreover, 8-hydroxy-2-deoxyguanosine, a marker for oxidative DNA damage, is significantly increased in the serum patients with dilated cardiomyopathy (Kono et al., 2006), and the concentration in the urine correlates with heart failure (Kobayashi et al., 2011)
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