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124 For example, BM-MSC-EVs can transfer miR-21 and target ten-eleven translocation 1 (TET1) to inhibit Kruppel-like factor 4 (KLF4) expression, promote fibroblast-like FLS proliferation, and downregulate the expression of inflammatory factors, such as IL-1β, TNF-α, PGE2, NO, and iNOS
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