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This process, known as tendon-to-bone integration, is biologically complex and includes: Mesenchymal stem cell activation New bone formation Collagen remodeling and alignment Revascularization (new blood vessel growth) It is one of the most demanding healing processes in the body
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Thus, the nutraceutical potential of flavonoids is supported by not only targeting inflammatory signaling (e.g., MAPK, NFκB and NLRP3), but also by stimulating antioxidant programs regulated by Nrf2, and their intrinsic structural antioxidant activities
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