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However, while HFI 419 exerts a proven cognitive-enhancing effect in rodents after icv administration similar to that of Ang IV 1 and LVV-H7 3 , the Ki value of 420 nM seems not optimal
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On the other hand, the vicious course induced by high intra-abdominal pressure can be simultaneously initiated and perpetuated from different sites (it should be noted that intracranial hypertension may essentially cause pulmonary edema and impair pulmonary circulation (Chen, 2009))
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