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Applications of dietary phytochemicals in food, cosmetic, nutrition, and pharmaceutical industries have seen an emerging trend due to their health-enhancing traits such as antiradical, antimicrobial, cardio-protectant, and gastro-protective properties ( Dietary phytochemicals include plant-derived alkaloids such as caffeine, carotenoids (e.g., carotene, cryptoxanthin, lutein, and lycopene), organosulfur compounds (e.g., isothiocyanates, indoles, and sulforaphane), phenolics (e.g., coumarins, flavonoids, phenolic acids, stilbenes, and tannins), phytosterols (e.g., avenasterol, campesterol, campestanol, citrostadienol, stigmasterol, stigmastanol, sitosterol, and sitostanol), tocols (e.g., tocopherols and tocotrienols), fatty acids, and volatile compounds

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This indicates that upregulation of endogenous polyamines, especially putrescine, serves as a critical mediator in BBB injury